Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.
Identifieur interne : 000507 ( Main/Exploration ); précédent : 000506; suivant : 000508Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.
Auteurs : RBID : pubmed:23630420English descriptors
- KwdEn :
- Animals, Cell Line, Tumor, Drug Carriers (chemistry), Drug Carriers (diagnostic use), Drug Carriers (pharmacokinetics), Heat-Shock Proteins (metabolism), Heterografts, Humans, Indium Radioisotopes (chemistry), Indium Radioisotopes (diagnostic use), Indium Radioisotopes (pharmacokinetics), Mice, Mice, Nude, Micelles, Molecular Imaging (methods), Particle Size, Peptides (chemistry), Peptides (diagnostic use), Peptides (pharmacokinetics), Radiopharmaceuticals (chemistry), Radiopharmaceuticals (diagnostic use), Radiopharmaceuticals (pharmacokinetics), Stomach Neoplasms (metabolism), Stomach Neoplasms (radionuclide imaging), Tumor Markers, Biological (metabolism).
- MESH :
- chemical , chemistry : Drug Carriers, Indium Radioisotopes, Peptides, Radiopharmaceuticals.
- chemical , diagnostic use : Drug Carriers, Indium Radioisotopes, Peptides, Radiopharmaceuticals.
- chemical , metabolism : Heat-Shock Proteins, Tumor Markers, Biological.
- chemical , pharmacokinetics : Drug Carriers, Indium Radioisotopes, Peptides, Radiopharmaceuticals.
- metabolism : Stomach Neoplasms.
- methods : Molecular Imaging.
- radionuclide imaging : Stomach Neoplasms.
- Animals, Cell Line, Tumor, Heterografts, Humans, Mice, Mice, Nude, Micelles, Particle Size.
Abstract
Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric micelles were designed and manufactured for nuclear imaging detection of tumors. Thiolated GRP78 binding peptide (GRP78BP) was first labeled with maleimide-terminated poly(ethylene glycol)- poly(ɛ-caprolactone) and then mixed with diethylenetriaminepentaacetic acid (DTPA)-linked poly(ethylene glycol)-poly(ɛ-caprolactone) to form DTPA/GRP78BP-conjugated micelles. The coupling efficiency of micelles with radioisotope indium-111 ((111)In) was measured and analyzed by instant thin layer chromatography. The coupling efficiency of DTPA-conjugated micelles and DTPA/GRP78BP-conjugated micelles with (111)In was 85% and 93%, respectively. For characterization and trace imaging, the radioisotope (111)In-targeting tumors were detected and imaged in a xenograft murine model using nano single photon emission computed tomography/computed tomography. The results revealed that the radioactive intensity measured in the animals administered with GRP78BP-guided (111)In-labeled micelles was statistically higher than that in animals administered with (111)In-labeled micelles, demonstrating that GRP78BP more than doubled the accumulation of micelles to the tumor tissue (P < 0.05). The results indicate that the gastric cancer biomarker GRP78 is a probing target in the application of nuclear imaging for tumor diagnosis. This novel GRP78BP-guided micelle agent may be applied in clinical practice to complement the histological diagnosis.
DOI: 10.2147/IJN.S42003
PubMed: 23630420
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Le document en format XML
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<author><name sortKey="Cheng, Chun Chia" uniqKey="Cheng C">Chun-Chia Cheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">République de Chine (Taïwan)</country>
<wicri:regionArea>Graduate Institute of Medical Sciences, Taipei Medical University, Taipei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Chiung Fang" uniqKey="Huang C">Chiung-Fang Huang</name>
</author>
<author><name sortKey="Ho, Ai Sheng" uniqKey="Ho A">Ai-Sheng Ho</name>
</author>
<author><name sortKey="Peng, Cheng Liang" uniqKey="Peng C">Cheng-Liang Peng</name>
</author>
<author><name sortKey="Chang, Chun Chao" uniqKey="Chang C">Chun-Chao Chang</name>
</author>
<author><name sortKey="Mai, Fu Der" uniqKey="Mai F">Fu-Der Mai</name>
</author>
<author><name sortKey="Chen, Ling Yun" uniqKey="Chen L">Ling-Yun Chen</name>
</author>
<author><name sortKey="Luo, Tsai Yueh" uniqKey="Luo T">Tsai-Yueh Luo</name>
</author>
<author><name sortKey="Chang, Jungshan" uniqKey="Chang J">Jungshan Chang</name>
</author>
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<publicationStmt><date when="2013">2013</date>
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<term>Cell Line, Tumor</term>
<term>Drug Carriers (chemistry)</term>
<term>Drug Carriers (diagnostic use)</term>
<term>Drug Carriers (pharmacokinetics)</term>
<term>Heat-Shock Proteins (metabolism)</term>
<term>Heterografts</term>
<term>Humans</term>
<term>Indium Radioisotopes (chemistry)</term>
<term>Indium Radioisotopes (diagnostic use)</term>
<term>Indium Radioisotopes (pharmacokinetics)</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Micelles</term>
<term>Molecular Imaging (methods)</term>
<term>Particle Size</term>
<term>Peptides (chemistry)</term>
<term>Peptides (diagnostic use)</term>
<term>Peptides (pharmacokinetics)</term>
<term>Radiopharmaceuticals (chemistry)</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>Radiopharmaceuticals (pharmacokinetics)</term>
<term>Stomach Neoplasms (metabolism)</term>
<term>Stomach Neoplasms (radionuclide imaging)</term>
<term>Tumor Markers, Biological (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Drug Carriers</term>
<term>Indium Radioisotopes</term>
<term>Peptides</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Drug Carriers</term>
<term>Indium Radioisotopes</term>
<term>Peptides</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heat-Shock Proteins</term>
<term>Tumor Markers, Biological</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Drug Carriers</term>
<term>Indium Radioisotopes</term>
<term>Peptides</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Heterografts</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Micelles</term>
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<front><div type="abstract" xml:lang="en">Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric micelles were designed and manufactured for nuclear imaging detection of tumors. Thiolated GRP78 binding peptide (GRP78BP) was first labeled with maleimide-terminated poly(ethylene glycol)- poly(ɛ-caprolactone) and then mixed with diethylenetriaminepentaacetic acid (DTPA)-linked poly(ethylene glycol)-poly(ɛ-caprolactone) to form DTPA/GRP78BP-conjugated micelles. The coupling efficiency of micelles with radioisotope indium-111 ((111)In) was measured and analyzed by instant thin layer chromatography. The coupling efficiency of DTPA-conjugated micelles and DTPA/GRP78BP-conjugated micelles with (111)In was 85% and 93%, respectively. For characterization and trace imaging, the radioisotope (111)In-targeting tumors were detected and imaged in a xenograft murine model using nano single photon emission computed tomography/computed tomography. The results revealed that the radioactive intensity measured in the animals administered with GRP78BP-guided (111)In-labeled micelles was statistically higher than that in animals administered with (111)In-labeled micelles, demonstrating that GRP78BP more than doubled the accumulation of micelles to the tumor tissue (P < 0.05). The results indicate that the gastric cancer biomarker GRP78 is a probing target in the application of nuclear imaging for tumor diagnosis. This novel GRP78BP-guided micelle agent may be applied in clinical practice to complement the histological diagnosis.</div>
</front>
</TEI>
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<DateCreated><Year>2013</Year>
<Month>04</Month>
<Day>30</Day>
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<DateCompleted><Year>2014</Year>
<Month>01</Month>
<Day>30</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1178-2013</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<PubDate><Year>2013</Year>
</PubDate>
</JournalIssue>
<Title>International journal of nanomedicine</Title>
<ISOAbbreviation>Int J Nanomedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.</ArticleTitle>
<Pagination><MedlinePgn>1385-91</MedlinePgn>
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<Abstract><AbstractText>Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric micelles were designed and manufactured for nuclear imaging detection of tumors. Thiolated GRP78 binding peptide (GRP78BP) was first labeled with maleimide-terminated poly(ethylene glycol)- poly(ɛ-caprolactone) and then mixed with diethylenetriaminepentaacetic acid (DTPA)-linked poly(ethylene glycol)-poly(ɛ-caprolactone) to form DTPA/GRP78BP-conjugated micelles. The coupling efficiency of micelles with radioisotope indium-111 ((111)In) was measured and analyzed by instant thin layer chromatography. The coupling efficiency of DTPA-conjugated micelles and DTPA/GRP78BP-conjugated micelles with (111)In was 85% and 93%, respectively. For characterization and trace imaging, the radioisotope (111)In-targeting tumors were detected and imaged in a xenograft murine model using nano single photon emission computed tomography/computed tomography. The results revealed that the radioactive intensity measured in the animals administered with GRP78BP-guided (111)In-labeled micelles was statistically higher than that in animals administered with (111)In-labeled micelles, demonstrating that GRP78BP more than doubled the accumulation of micelles to the tumor tissue (P < 0.05). The results indicate that the gastric cancer biomarker GRP78 is a probing target in the application of nuclear imaging for tumor diagnosis. This novel GRP78BP-guided micelle agent may be applied in clinical practice to complement the histological diagnosis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Chun-Chia</ForeName>
<Initials>CC</Initials>
<Affiliation>Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.</Affiliation>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Chiung-Fang</ForeName>
<Initials>CF</Initials>
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<Author ValidYN="Y"><LastName>Ho</LastName>
<ForeName>Ai-Sheng</ForeName>
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<ForeName>Cheng-Liang</ForeName>
<Initials>CL</Initials>
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<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Chun-Chao</ForeName>
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<Author ValidYN="Y"><LastName>Mai</LastName>
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<Initials>J</Initials>
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<Language>eng</Language>
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<Month>04</Month>
<Day>10</Day>
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<MedlineJournalInfo><Country>New Zealand</Country>
<MedlineTA>Int J Nanomedicine</MedlineTA>
<NlmUniqueID>101263847</NlmUniqueID>
<ISSNLinking>1176-9114</ISSNLinking>
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